Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors

…, P Gupta, PP Yadav, P Tiwari, AK Tamrakar…

Index: Ahmad, Ghufran; Mishra, Pushpesh K.; Gupta, Prasoon; Yadav, Prem P.; Tiwari, Priti; Tamrakar, Akhilesh K.; Srivastava, Arvind K.; Maurya, Rakesh Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2139 - 2143

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Citation Number: 38

Abstract

PTPases are considered to be involved in the etiology of diabetes mellitus and neural diseases, such as Alzheimer's disease and Parkinson's disease. Therefore, PTPase inhibitors should be useful tools to study the role of PTPases in these diseases and other biological phenomena, and which can be developed into chemotherapeutic agents. In the present study, we have synthesized novel benzofuran isoxazolines 13–21 via 1, 3-dipolar ...