Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors

…, P Gupta, PP Yadav, P Tiwari, AK Tamrakar…

文献索引：Ahmad, Ghufran; Mishra, Pushpesh K.; Gupta, Prasoon; Yadav, Prem P.; Tiwari, Priti; Tamrakar, Akhilesh K.; Srivastava, Arvind K.; Maurya, Rakesh Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2139 - 2143

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被引用次数: 38

摘要

PTPases are considered to be involved in the etiology of diabetes mellitus and neural diseases, such as Alzheimer's disease and Parkinson's disease. Therefore, PTPase inhibitors should be useful tools to study the role of PTPases in these diseases and other biological phenomena, and which can be developed into chemotherapeutic agents. In the present study, we have synthesized novel benzofuran isoxazolines 13–21 via 1, 3-dipolar ...