Efficient Synthesis of Quinoxaline Derivatives by Selective Modification of 3??Chloro??6??fluoroquinoxalin??2 (1H)??one 4??Oxide

…, B Bergmann, IB Müller, DE Kaufmann

Index: Maichrowski, Jan; Gjikaj, Mimoza; Huebner, Eike G.; Bergmann, Baerbel; Mueller, Ingrid B.; Kaufmann, Dieter E. European Journal of Organic Chemistry, 2013 , # 11 p. 2091 - 2105

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Citation Number: 3

Abstract

Abstract The readily available and polyfunctionalized 3-chloro-6-fluoroquinoxalin-2 (1H)- one 4-oxide, derived from the efficient one-step annulation reaction of 1, 1, 2-trichloro-2- nitroethene with 4-fluoroaniline, was selectively modified at the chloronitrone and the amide units, leading to more than 30 new quinoxaline derivatives with a unique substitution pattern in good to excellent yields. In addition, the electronic properties of the versatile starting ...