3-(4-Phenoxyphenyl) pyrazoles: a novel class of sodium channel blockers

J Yang, P Gharagozloo, J Yao, VI Ilyin…

Index: Jean-Claude, Bertrand J.; Just, George Heterocycles, 1998 , vol. 48, # 7 p. 1347 - 1363

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Citation Number: 44

Abstract

... J. Med. ... of neuropathic pain (Chart 1). 15,16 Still, these compounds were developed as anticonvulsants and are only weakly active ... It was envisaged that heterocyclic bioisosteres of the semicarbazone moiety would give analogues with improved metabolic stability and solubility. ...