Molecules

Benzamidomethylation with (Benzamidomethyl) triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids

E Popovski, L Klisarova

Index: Popovski, Emil; Klisarova, Ljiljana; Vikic-Topic, Drazen Molecules, 2000 , vol. 5, # 7 p. 927 - 936

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Citation Number: 13

Abstract

Abstract Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl) triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH> 9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di (benzamidomethyl) amines (5) were obtained in high yields (> 90%) as well as S (CH 2 NHBz) 2 in a reaction of 1 with Na 2 S. Benzamidomethyl ...