Probing the “Active Site” of Diamine Oxidase: Structure-Activity Relations for Histamine Potentiation byO-Alkylhydroxylamines on Colonic Epithelium

A High, T Prior, RA Bell, PK Rangachari

Index: High; Prior; Bell; Rangachari Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 2 p. 490 - 501

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Citation Number: 14

Abstract

Abstract The responses of the canine colonic epithelium to histamine are potentiated by O- alkylhydroxylamines. A study of a series of such compounds suggested that active compounds had the structure RO-NH 2, substitution of a nitrogen led to total loss of activity. The locus of the potentiation effect was traced to the inhibition of diamine oxidase. A new series of aliphatic and aromatic O-alkylhydroxylamines were synthesized to explore ...