N-Hydroxyphthalimide

Modify Date: 2026-06-30 15:10:35

N-Hydroxyphthalimide Structure
N-Hydroxyphthalimide structure
Common Name N-Hydroxyphthalimide
CAS Number 524-38-9 Molecular Weight 163.130
Density 1.6±0.1 g/cm3 Boiling Point 370.3±25.0 °C at 760 mmHg
Molecular Formula C8H5NO3 Melting Point 233 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 177.8±23.2 °C

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name N-Hydroxyphthalimide
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.6±0.1 g/cm3
Boiling Point 370.3±25.0 °C at 760 mmHg
Melting Point 233 °C (dec.)(lit.)
Molecular Formula C8H5NO3
Molecular Weight 163.130
Flash Point 177.8±23.2 °C
Exact Mass 163.026947
PSA 57.61000
LogP 0.42
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.718
InChIKey CFMZSMGAMPBRBE-UHFFFAOYSA-N
SMILES O=C1c2ccccc2C(=O)N1O
Storage condition Store at RT.

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TI5200000
CHEMICAL NAME :
Phthalimide, N-hydroxy-
CAS REGISTRY NUMBER :
524-38-9
BEILSTEIN REFERENCE NO. :
0131208
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H5-N-O3
MOLECULAR WEIGHT :
163.14
WISWESSER LINE NOTATION :
T56 BVNVJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00747

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TI5200000
HS Code 29251995

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2925190090
Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles20

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Bromide-free oxidizing system for carboxylic moiety formation in cellulose chain.

Carbohydr. Polym. 90(4) , 1415-9, (2012)

NHPI (N-hydroxyphthalimide) was used to mediate the oxidation of cellulose fibers in the absence of sodium bromide, as traditionally was used in this kind of transformations, solely using sodium hypoc...

Anthrone-derived NHPI analogues as catalysts in reactions using oxygen as an oxidant.

Org. Biomol. Chem. 6(22) , 4096-8, (2008)

An enantioselective synthesis of anthrone-derived NHPI analogues has been developed. One of these analogues, in combination with Co salts, was employed to catalyse the aerobic oxidation of benzylic co...

Oxidized cellulose--survey of the most recent achievements.

Carbohydr. Polym. 93(1) , 207-15, (2013)

The functionalization and particularly the oxidation of cellulose is an intriguing and challenging topic due to the presence of multiple reactive sites, which can undergo specific reactions. The varie...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

nhpi
N-Hydroxy Phthalimide
2-Hydroxy-1H-isoindole-1,3(2H)-dione
2-hydroxyisoindoline-1,3-dione
N-Hydroxyphthalimide
HOPHT
EINECS 208-358-1
N-hydroxylphthalimide
phthalamohydroxamic acid
PHTHALOXIME
N-hydroxyphtalimide
n-hydroxy-phthalimid
MFCD00005891
hydroxyphthalimide
NHPI NOP
N-hydroxy-phthalimide
2-hydroxy-1,3-isoindolinedione

 N-Hydroxyphthalimide | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of N-Hydroxyphthalimide?
A: Molecular formula of N-Hydroxyphthalimide is C8H5NO3.
Q: What is the LogP of N-Hydroxyphthalimide?
A: LogP of N-Hydroxyphthalimide is 0.42.
Q: What is the molecular weight of N-Hydroxyphthalimide?
A: Molecular weight of N-Hydroxyphthalimide is 163.130.
Q: What English synonyms does N-Hydroxyphthalimide have?
A: English synonyms of N-Hydroxyphthalimide: nhpi, N-Hydroxy Phthalimide, 2-Hydroxy-1H-isoindole-1,3(2H)-dione, 2-hydroxyisoindoline-1,3-dione, N-Hydroxyphthalimide, HOPHT, EINECS 208-358-1, N-hydroxylphthalimide, phthalamohydroxamic acid, PHTHALOXIME, N-hydroxyphtalimide, n-hydroxy-phthalimid, MFCD00005891, hydroxyphthalimide, NHPI NOP, N-hydroxy-phthalimide, 2-hydroxy-1,3-isoindolinedione.
Q: What are the upstream materials of N-Hydroxyphthalimide?
A: Related upstream materials(CAS) of N-Hydroxyphthalimide: 85-44-9;150220-29-4;16653-19-3;57685-30-0;84-66-2;6383-59-1;71-43-2;88-95-9.
Q: What is the safety information for N-Hydroxyphthalimide?
A: Safety information for N-Hydroxyphthalimide: S26-S36-S37/39.
Q: What is the polar surface area (PSA) of N-Hydroxyphthalimide?
A: Polar surface area (PSA) of N-Hydroxyphthalimide is 57.61000.
Q: What are the storage conditions for N-Hydroxyphthalimide?
A: Storage conditions for N-Hydroxyphthalimide: Store at RT.
Q: What is the SMILES notation of N-Hydroxyphthalimide?
A: SMILES notation of N-Hydroxyphthalimide is O=C1c2ccccc2C(=O)N1O.
Q: What is the InChIKey of N-Hydroxyphthalimide?
A: InChIKey of N-Hydroxyphthalimide is CFMZSMGAMPBRBE-UHFFFAOYSA-N.

 N-Hydroxyphthalimidefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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