Tetrahedron

Three-component one-pot process to propargylic amines and related amide and sulfonamide compounds: application to the construction of 2-(aminomethyl) …

…, JF Peyrat, JD Brion, S Sicsic, I Berque-Bestel, M Alami

Index: Russo, Olivier; Messaoudi, Samir; Hamze, Abdallah; Olivi, Nathanaeel; Peyrat, Jean-Francois; Brion, Jean-Daniel; Sicsic, Sames; Berque-Bestel, Isabelle; Alami, Mouad Tetrahedron, 2007 , vol. 63, # 43 p. 10671 - 10683

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Citation Number: 26

Abstract

An efficient palladium–copper-catalyzed three-component assembling of propargyl halides, aryl or heteroaryl halides, and secondary amines is described. A wide variety of tertiary propargylic amines were synthesized in good to excellent yields from easily accessible starting materials. This three-component assembling was also effective when using potassium phthalimide or di-tert-butyliminodicarbonate instead of secondary amines. ...