A Rhodium??Catalyzed Cascade Cyclization: Direct Synthesis of N??Substituted Phthalimides from Isocyanates and Benzoic Acids

XY Shi, A Renzetti, S Kundu…

Index: Shi, Xian-Ying; Renzetti, Andrea; Kundu, Soumen; Li, Chao-Jun Advanced Synthesis and Catalysis, 2014 , vol. 356, # 4 p. 723 - 728

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Citation Number: 27

Abstract

Abstract: A rhodiumACHTUNGTRENNUNG (III)-catalyzed amidation between benzoic acids and isocyanates via direct functionalization of an ortho CÀH bond followed by intramolecular cyclization is described. This cascade cyclization affords N-substituted phthalimides in one step in 26–91% yields. The reaction is highly atom-economical, since no theoretical waste except for water is generated in the reaction. Keywords: amidation; CÀH activation; ...