Reactions of carbonyl compounds with Grignard reagents in the presence of cerium chloride

T Imamoto, N Takiyama, K Nakamura…

Index: Imamoto, Tsuneo; Takiyama, Noboyuki; Nakamura, Kimikazu; Hatajima, Toshihiko; Kamiya, Yasuo Journal of the American Chemical Society, 1989 , vol. 111, # 12 p. 4392 - 4398

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Citation Number: 555

Abstract

Abstract: The addition of Grignard reagents to ketones is significantly enhanced by cerium chloride with remarkable suppression of side reactions, particularly enolization. Some esters, which are prone to side reactions, also react readily with Grignard reagents in the presence of cerium chloride to give normal reaction products in reasonable to high yields.