Synthesis of isotopically labelled L??phenylalanine and L??tyrosine

J Raap, S Nieuwenhuis, A Creemers…

Index: Raap, Jan; Nieuwenhuis, Saskia; Creemers, Alain; Hexspoor, Sander; Kragl, Udo; Lugtenburg, Johan European Journal of Organic Chemistry, 1999 , # 10 p. 2609 - 2621

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Citation Number: 32

Abstract

Abstract A synthetic route to stable-isotope-substituted L-phenylalanine is presented, which allows the introduction of 13 C, 15 N, and deuterium labels at any position or combination of positions. For labelling of the aromatic ring, a synthetic route to ethyl benzoate (or benzonitrile) has been developed, based on the electrocyclic ring-closure of a 1, 6- disubstituted hexatriene system, with in situ aromatization by elimination of one (amino) ...