Tetrahedron Letters

Direct benzylation and allylic alkylation in high-temperature water without added catalysts

T Hirashita, S Kuwahara, S Okochi, M Tsuji, S Araki

Index: Hirashita, Tsunehisa; Kuwahara, Sho; Okochi, Sota; Tsuji, Makoto; Araki, Shuki Tetrahedron Letters, 2010 , vol. 51, # 14 p. 1847 - 1851

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Citation Number: 27

Abstract

There is no need for preparing individual reactive species and water as an only by-product seems to be highly attractive. These type reactions have hitherto been achieved using Lewis acids, 2, 3, 4 and 5 Brønsted acids, 6 and iodine 7 in organic solvents. Water is undoubtedly a greener solvent than organic solvents. The salient features of water in organic syntheses, exemplified by acceleration of reactions and enhancement of selectivities, have prompted organic ...