Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

TP Petersen, AF Larsen, A Ritzén…

Index: Petersen, Trine P.; Larsen, Anders Foller; Ritzen, Andreas; Ulven, Trond Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4190 - 4195

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Citation Number: 16

Abstract

Aryldimethylamines can be prepared by nucleophilic aromatic substitution (S N Ar) of aryl or heteroaryl halides with dimethylamine. However, because of the volatile nature of this reagent and the high temperatures or long reaction times often required,(1) outgassing from open flask reactors or pressure build-up under sealed-tube conditions can be problematic. Rather than using a premade solution, dimethylamine can be produced in situ from thermal ...