Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

…, A Abuhammad, DL Wilson, MC Anderton…

Index: Fullam, Elizabeth; Abuhammad, Areej; Wilson, David L.; Anderton, Matthew C.; Davies, Steve G.; Russell, Angela J.; Sim, Edith Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1185 - 1190

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Citation Number: 12

Abstract

The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3′-(4 ″-cyclopent-2‴-en-1‴-ylphenoxy)-2′-hydroxypropyl]-5, 5 dimethylimidazolidine-2, 4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.