The Journal of Organic Chemistry

Decarboxylation of indole-2-carboxylic acids: improved procedures

GB Jones, BJ Chapman

Index: Jones, Graham B.; Chapman, Brant J. Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5558 - 5559

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Citation Number: 60

Abstract

Of the many synthetic avenues to 2-unsubstituted indoles available, classical approaches including the Reissert,'Fischer? and Rees-Moody3 routes require subsequent removal of the 2-carboxyl function. Several procedures have been reported to effect this problematic transformation with widely ranging degrees of efficiency. 4-Problems encountered during the process usually stem from decomposition of the product under prolonged thermolysis ...