Synthesis and antiviral activity of certain 9-. beta.-D-ribofuranosylpurine-6-carboxamides

JD Westover, GR Revankar, RK Robins…

Index: Westover, James D.; Revankar, Ganapathi R.; Robins, Roland K.; Madsen, Randall D.; Ogden, John R.; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 941 - 946

Full Text: HTML

Citation Number: 34

Abstract

To examine the structural parameters necessary for antiviral efficacy of certain purine nucleosides, several QBD-ribofuranosylpurine-6-carboxamides have been synthesized. Glycosylation of the Me3Si derivative of purine-6-carboxamide with protected ribofuranose in the presence of a Lewis acid gave the blocked nucleoside which on deprotection furnished 9-BD-ribofuranosylpurine-Gcarboxamide (6a). Alternatively, 6a was synthesized ...