Synthesis

Structure elucidation and enantioselective total synthesis of the HMG-CoA reductase inhibitors FR901512 and FR901516

M Inoue, M Nakada

Index: Inoue, Masahiro; Nakada, Masahisa Synthesis, 2009 , # 21 p. 3694 - 3707

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Citation Number: 2

Abstract

Abstract The enantioselective total synthesis of the potent HMG-CoA reductase inhibitors FR901512 (1) and FR901516 (2) is reviewed. FR901512 was prepared in 15 steps from commercially available compound via 2 in 16.3% overall yield (89% average yield). This study validated the applicability and reliability of the catalytic asymmetric Nozaki-Hiyama reactions that were developed by us. These reactions enabled the concise, efficient, and ...