Tetrahedron

Aza-Michael reaction: selective mono-versus bis-addition under environmentally-friendly conditions

G Bosica, J Spiteri, C Borg

Index: Bosica, Giovanna; Spiteri, Jonathan; Borg, Caroline Tetrahedron, 2014 , vol. 70, # 14 p. 2449 - 2454

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Citation Number: 6

Abstract

Abstract Aza-Michael reactions between primary amines and methyl propenoate have been investigated under environmentally-friendly solventless heterogeneous catalysis in order to obtain the mono-or the bis-adduct. The reaction conditions can be altered so as to maximise the yields of the required product with high selectivity.