Preparation of [1, 2, 3, 4, 5??13C5]??5??Amino??4??oxopentanoic Acid (ALA)− Design of a Synthetic Scheme to Prepare Any 13C??and 15N??Isotopomer with High Isotopic …

PB Shrestha??Dawadi…

Index: Shrestha-Dawadi, Prativa Bade; Lugtenburg, Johan European Journal of Organic Chemistry, 2003 , # 23 p. 4654 - 4663

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Citation Number: 11

Abstract

Abstract 5-Amino-4-oxopentanoic acid (5-aminolevulinic acid) is a precursor in the biosynthesis of the biologically active porphyrins such as chlorophyll, bacteriochlorophyll, heme, etc. These systems are central in photosynthesis, oxygen transport, electron transport, etc. In this paper we describe a simple scheme to prepare any isotopomer of 5- aminolevulinic acid in a few steps in high yield. Using a similar scheme, levulinic acid can ...