5-Aminolevulinic acid hydrochloride
Modify Date: 2025-08-22 19:14:14
5-Aminolevulinic acid hydrochloride structure
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Common Name | 5-Aminolevulinic acid hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 5451-09-2 | Molecular Weight | 167.59 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 311.5±27.0 °C at 760 mmHg | |
| Molecular Formula | C5H10ClNO3 | Melting Point | ~150 °C (dec.) | |
| MSDS | Chinese USA | Flash Point | 142.2±23.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 5-Aminolevulinic acid hydrochloride5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2]. |
| Name | 5-Aminolevulinic Acid Hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | 5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 311.5±27.0 °C at 760 mmHg |
| Melting Point | ~150 °C (dec.) |
| Molecular Formula | C5H10ClNO3 |
| Molecular Weight | 167.59 |
| Flash Point | 142.2±23.7 °C |
| PSA | 80.39000 |
| LogP | -0.79 |
| Appearance of Characters | powder |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.482 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: 50 mg/mL |
CHEMICAL IDENTIFICATION
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi,Xn |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . R66:Repeated exposure may cause skin dryness or cracking. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . |
| Safety Phrases | S26-S36/37-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | OI1640000 |
| HS Code | 2922509090 |
| Precursor 7 | |
|---|---|
| DownStream 6 | |
CAS#:839724-53-7
CAS#:159150-70-6
CAS#:93393-93-2
CAS#:109258-71-1
CAS#:155585-41-4
CAS#:53856-93-2
CAS#:142-08-5
CAS#:487-90-1
CAS#:79416-27-6
CAS#:106-60-5
CAS#:72072-06-1
CAS#:77479-02-8
CAS#:77479-03-9| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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| 5-Aminolevulinic acid hydrochloride |
| MFCD00012869 |
| EINECS 226-679-5 |
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