A Modular Synthesis of Teraryl??Based α??Helix Mimetics, Part 1: Synthesis of Core Fragments with Two Electronically Differentiated Leaving Groups

…, R Kleineweischede, R Breinbauer

Index: Peters, Martin; Trobe, Melanie; Tan, Hao; Kleineweischede, Rolf; Breinbauer, Rolf Chemistry - A European Journal, 2013 , vol. 19, # 7 p. 2442 - 2449

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Citation Number: 20

Abstract

Abstract Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein–protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics. Central to our strategy is the use of a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd- catalyzed cross-coupling used for terphenyl assembly. With the halogen/diazonium route ...