2-Chloroacetamide

Modify Date: 2026-06-30 06:10:48

2-Chloroacetamide structure	Common Name	2-Chloroacetamide
	CAS Number	79-07-2	Molecular Weight	93.512
	Density	1.3±0.1 g/cm3	Boiling Point	256.0±13.0 °C at 760 mmHg
	Molecular Formula	C₂H₄ClNO	Melting Point	116-118 °C(lit.)
	MSDS	Chinese USA	Flash Point	108.6±19.8 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of 2-Chloroacetamide

2-Chloroacetamide is a preservative and is a herbicide for both uplands and paddy fields. 2-Chloroacetamide is a biocide in agriculture, glues, paints and coatings. 2-Chloroacetamide inhibits very-long-chain fatty acid elongase[1][2][3].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Chloroacetamide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	2-Chloroacetamide is a preservative and is a herbicide for both uplands and paddy fields. 2-Chloroacetamide is a biocide in agriculture, glues, paints and coatings. 2-Chloroacetamide inhibits very-long-chain fatty acid elongase[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Hidenori Okamoto, et al. Synthesis and Herbicidal Activity of N(1-Arylethenyl)-2-chloroacetamides. Agricultural and Biological Chemistry, Volume 55, 1991-Issue 11. [2]. A Fonia, et al. Active Sensitization to Chloracetamide. Contact Dermatitis. 2009 Jan;60(1):58-9. [3]. Christian Eckermann, et al. Covalent Binding of Chloroacetamide Herbicides to the Active Site Cysteine of Plant Type III Polyketide Synthases. Phytochemistry. 2003 Nov;64(6):1045-54.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Hidenori Okamoto, et al. Synthesis and Herbicidal Activity of N(1-Arylethenyl)-2-chloroacetamides. Agricultural and Biological Chemistry, Volume 55, 1991-Issue 11.

[2]. A Fonia, et al. Active Sensitization to Chloracetamide. Contact Dermatitis. 2009 Jan;60(1):58-9.

[3]. Christian Eckermann, et al. Covalent Binding of Chloroacetamide Herbicides to the Active Site Cysteine of Plant Type III Polyketide Synthases. Phytochemistry. 2003 Nov;64(6):1045-54.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	256.0±13.0 °C at 760 mmHg
Melting Point	116-118 °C(lit.)
Molecular Formula	C₂H₄ClNO
Molecular Weight	93.512
Flash Point	108.6±19.8 °C
Exact Mass	92.998138
PSA	43.09000
LogP	-0.85
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.448
InChIKey	VXIVSQZSERGHQP-UHFFFAOYSA-N
SMILES	NC(=O)CCl

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2-Chloroacetamide MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB5075000

CHEMICAL NAME :: Acetamide, 2-chloro-

CAS REGISTRY NUMBER :: 79-07-2

BEILSTEIN REFERENCE NO. :: 0878191

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C2-H4-Cl-N-O

MOLECULAR WEIGHT :: 93.52

WISWESSER LINE NOTATION :: ZV1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 155 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 960 mg/kg/30D-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Cardiac - EKG changes not diagnostic of specified effects Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 210,255,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1156 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 90 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H317-H361f
Precautionary Statements	P201-P280-P301 + P310 + P330-P308 + P313-P333 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R43;R62
Safety Phrases	S22-S36/37-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	2
RTECS	AB5075000
Packaging Group	III
Hazard Class	6.1
HS Code	29241900

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:79-04-9 Chloroacetyl ch... CAS#:541-88-8 Chloroacetic an... CAS#:96-34-4 methyl chloroacetate CAS#:598-42-5 glycolamide
CAS#:35070-77-0 N-chloro-alpha-... CAS#:7732-18-5 Water CAS#:53663-25-5 N-methyl-1,2-di... CAS#:109-76-2 1,3-Diaminopropane
CAS#:107-14-2 2-chloroacetonitrile
DownStream 10
CAS#:110578-98-8 2-[(2-methyl-5-... CAS#:110578-99-9 ACETAMIDE, 2-((... CAS#:35008-50-5 (phenylsulfonyl... CAS#:59564-59-9 3,4-dihydroquin...
CAS#:39796-49-1 2-(benzylamino)... CAS#:5689-59-8 N-(1-adamantyl)... CAS#:39522-26-4 6-METHYL-2H-1,4... CAS#:3182-77-2 Glycine, N-2-pr...
CAS#:5625-67-2 2-Piperazinone CAS#:5625-98-9 2-PHENYL-5-OXAZOLONE

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells.

Oncotarget 6(8) , 6014-28, (2015)

Alpha fetoprotein (AFP) is a clinical biomarker of hepatocellular carcinoma (HCC). Here, we found that miR-1236 is down-regulated, whereas AFP is highly expressed in HCC tissues and cells. We demonstr...

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

EMBO Rep. 16 , 939-54, (2015)

Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity bot...

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.

Proc. Natl. Acad. Sci. U. S. A. 111(37) , E3880-9, (2014)

Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is ...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788

Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Total 133, Current Page 1 of 14

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 201-174-2

2-Chloroacetamide

MFCD00008027

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of Chloroacetamide?

A: The English name of Chloroacetamide is Chloroacetamide.

Q: What is the CAS number of Chloroacetamide?

A: CAS number of Chloroacetamide is 79-07-2.

Q: What is the safety information for Chloroacetamide?

A: Safety information for Chloroacetamide: S22-S36/37-S45.

Q: What is the melting point of Chloroacetamide?

A: Melting point of Chloroacetamide is 116-118 °C(lit.).

Q: What is the polar surface area (PSA) of Chloroacetamide?

A: Polar surface area (PSA) of Chloroacetamide is 43.09000.

Q: What are the upstream materials of Chloroacetamide?

A: Related upstream materials(CAS) of Chloroacetamide: 79-04-9;541-88-8;96-34-4;598-42-5;35070-77-0;7732-18-5;53663-25-5;109-76-2;107-14-2.

Q: What are the uses of Chloroacetamide?

A: Main uses of Chloroacetamide: 2-Chloroacetamide is a preservative and is a herbicide for both uplands and paddy fields. 2-Chloroacetamide is a biocide in agriculture, glues, paints and coatings. 2-Chloroacetamide inhibits very-long-chain fatty acid elongase[1][2][3].

Q: What is the molecular formula of Chloroacetamide?

A: Molecular formula of Chloroacetamide is C2H4ClNO.

Q: What is the InChIKey of Chloroacetamide?

A: InChIKey of Chloroacetamide is VXIVSQZSERGHQP-UHFFFAOYSA-N.

Q: What is the boiling point of Chloroacetamide?

A: Boiling point of Chloroacetamide is 256.0±13.0 °C at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Chloroacetamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 79-07-2 Chloroacetamide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2-Chloroacetamide
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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