Versatile One??Pot Reductive Alkylation of Lactams/Amides via Amide Activation: Application to the Concise Syntheses of Bioactive Alkaloids (±)??Bgugaine,(±)?? …

…, Y Wang, KY Ye, PQ Huang

Index: Xiao, Kai-Jiong; Wang, Yu; Ye, Ke-Yin; Huang, Pei-Qiang Chemistry - A European Journal, 2010 , vol. 16, # 43 p. 12792 - 12796

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Citation Number: 56

Abstract

Efficiency is the central goal in organic synthesis.[1] Towards this goal, the development of one-pot multicomponent reactions [2] and step-economy synthesis [3] constitute two valuable approaches. In this context, we have recently reported the first general one-pot method for the transformation of lactams and amides into the corresponding tert-alkylamines [4] by bis-reductive alkylation with different organometallic reagents (Scheme 1).[4a] α- ...