Abstract Gatifloxacin isomers,[1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7-(2-methyl-1- piperazinyl)-4-oxo-3-quinoline carboxylic acid] and a series of its derivatives were designed and synthesized and evaluated for their in vitro antibacterial activities. Preliminary results indicated that the tested compounds GI1, GI2, GI3 and GI4 demonstrated excellent activity against Staph. epidermidis. In addition, compounds GI1, GI3 and GI4 show MIC 0.015 μg/ ...
