Isonicotinic acid

Modify Date: 2025-08-20 17:26:02

Isonicotinic acid structure	Common Name	Isonicotinic acid
	CAS Number	55-22-1	Molecular Weight	123.109
	Density	1.3±0.1 g/cm3	Boiling Point	396.0±15.0 °C at 760 mmHg
	Molecular Formula	C₆H₅NO₂	Melting Point	≥300 °C(lit.)
	MSDS	Chinese USA	Flash Point	193.3±20.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of Isonicotinic acid

Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[1].

Name	isonicotinic acid
Synonym	More Synonyms

Description	Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[1].
Related Catalog	Research Areas >> Others
References	[1]. Seng KY, et al. Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers. Antimicrob Agents Chemother. 2015 Nov;59(11):6791-9.

Density	1.3±0.1 g/cm3
Boiling Point	396.0±15.0 °C at 760 mmHg
Melting Point	≥300 °C(lit.)
Molecular Formula	C₆H₅NO₂
Molecular Weight	123.109
Flash Point	193.3±20.4 °C
Exact Mass	123.032028
PSA	50.19000
LogP	0.54
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.571
Storage condition	-20°C
Water Solubility	5.2 g/L (20 ºC)

Isonicotinic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS1103000

CHEMICAL NAME :: Isonicotinic acid

CAS REGISTRY NUMBER :: 55-22-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H5-N-O2

MOLECULAR WEIGHT :: 123.12

WISWESSER LINE NOTATION :: T6NJ DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,481,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3123 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,481,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 436 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,481,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 23,1343,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6268 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	NS1103000
HS Code	2933399090

Precursor 10
CAS#:1453-82-3 Isonicotinamide CAS#:108-89-4 4-Picoline CAS#:13602-12-5 Pyridine-4-Carb... CAS#:54-85-3 Isoniazid
CAS#:100-48-1 Isonicotinonitrile CAS#:872-85-5 p-Formylpyridine CAS#:71653-47-9 4-methoxybenzyl... CAS#:638203-02-8 isopentenyl iso...
CAS#:54751-01-8 Pyridine,4-(bro... CAS#:586-95-8 4-Pyridinemethanol
DownStream 10
CAS#:36209-51-5 4-amino-5-(4-py... CAS#:54-85-3 Isoniazid CAS#:4329-75-3 1,2-Diisonicoti... CAS#:38634-05-8 (4-amino-3,5-bi...
CAS#:490-11-9 Cinchomeronic acid CAS#:33972-97-3 1-METHYL-2-OXO-... CAS#:54751-01-8 Pyridine,4-(bro... CAS#:59290-82-3 3-Nitroisonicot...
CAS#:586-95-8 4-Pyridinemethanol CAS#:108-89-4 4-Picoline

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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EINECS 200-228-2

4-Pyridinecarboxylic acid

g-Pyridinecarboxylic Acid

Pyridine-4-carboxylic acid

MFCD00006429

g-picolinic acid

Isonicotinic acid

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