Development of a general palladium-catalyzed carbonylative Heck reaction of aryl halides

…, H Neumann, A Spannenberg, T Schulz, H Jiao…

Index: Wu, Xiao-Feng; Neumann, Helfried; Spannenberg, Anke; Schulz, Thomas; Jiao, Haijun; Beller, Matthias Journal of the American Chemical Society, 2010 , vol. 132, # 41 p. 14596 - 14602

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Citation Number: 126

Abstract

Abstract: The first general palladium-catalyzed carbonylative vinylation of aryl halides with olefins in the presence of CO has been developed. Applying a catalyst system consisting of [(cinnamyl) PdCl] 2 and bulky imidazolylphosphine ligand L1 allows for the efficient and selective synthesis of R, β-unsaturated ketones under mild reaction conditions. Starting from easily available aryl halides and olefins, versatile building blocks can be prepared in a ...