DNA??Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

…, R Eritja, J Van Beeumen, P Herdewijn

Index: Lescrinier, Theo; Hendrix, Chris; Kerremans, Luc; Rozenski, Jef; Link, Andreas; Samyn, Bart; Van Aerschot, Arthur; Lescrinier, Eveline; Eritja, Ramon; Van Beeumen, Jozef; Herdewijn, Piet Chemistry - A European Journal, 1998 , vol. 4, # 3 p. 425 - 433

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Citation Number: 38

Abstract

Abstract Combinatorial chemistry with a newly-developed screening procedure using complementary fluorescein-and rhodamine-labelled oligonucleotides (below) has been used to select peptide dsDNA binding ligands. A high structure–affinity relationship of the dsDNA-binding unnatural peptide was observed.