Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa)

L Widler, KA Jaeggi, M Glatt, K Müller…

Index: Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3721 - 3738

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Citation Number: 291

Abstract

... Journal of Medicinal Chemistry. ... The first member of the second-generation BPs was pamidronate (1b, Table 1), originally synthesized by Henkel as an additive for detergents and subsequently licensed to Ciba-Geigy for development as a pharmaceutical agent (pamidronate ...

~6%

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