Tetrahedron

KF–Al 2 O 3 is an efficient solid support reagent for the acetylation of amines, alcohols, and phenols. Impeding effect of solvent on the reaction rate

VK Yadav, KG Babu, M Mittal

Index: Yadav, Veejendra K; Ganesh Babu; Mittal, Manish Tetrahedron, 2001 , vol. 57, # 32 p. 7047 - 7051

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Citation Number: 68

Abstract

KF–Al 2 O 3 brings about rapid acetylation of a range of amines, alcohols, and phenols with Ac 2 O/AcCl. Aliphatic alcohols are acetylated chemoselectively in the presence of phenols. 1° alcohols react several times faster than 2° alcohols. 3° alcohols do not react. ... Amines, alcohols and phenols are conveniently acetylated with the use of KF–Al 2 O 3 and AcCl/Ac 2 O in high yields. ... The acetylation of alcohols and amines is an important reaction in organic ...

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