Synthesis and Biological Evaluation of 2??Mercapto??1, 3??benzothiazole Derivatives with Potential Antimicrobial Activity

C Franchini, M Muraglia, F Corbo, MA Florio…

Index: Franchini, Carlo; Muraglia, Marilena; Corbo, Filomena; Florio, Marco Antonio; Di Mola, Antonia; Rosato, Antonio; Matucci, Rosanna; Nesi, Marta; Van Bambeke, Francoise; Vitali, Cesare Archiv der Pharmazie, 2009 , vol. 342, # 10 p. 605 - 613

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Citation Number: 50

Abstract

Abstract The enhancement of bacterial resistance of pathogens to currently available antibiotics constitutes a serious public health threat. So, intensive efforts are underway worldwide to develop new antimicrobial agents. To identify compounds with a potent antimicrobial profile, we designed and synthesized low molecular weight 2- mercaptobenzothiazole derivatives 2a–2l and 3a–3l. Both series were screened for in- ...