The regiospecific Fischer indole reaction in choline chloride· 2ZnCl 2 with product isolation by direct sublimation from the ionic liquid

RC Morales, V Tambyrajah, PR Jenkins…

Index: Morales, Raul Calderon; Tambyrajah, Vasuki; Jenkins, Paul R.; Davies, David L.; Abbott, Andrew P. Chemical Communications, 2004 , # 2 p. 158 - 159

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Citation Number: 57

Abstract

The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloride· 2ZnCl2; exclusive formation of 2, 3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.