A new synthesis of occidol

RB Mane, AJ Kadam

Index: Mane, Ramchandra Bhimrao; Kadam, Abhijit Jaysingrao Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 3 p. 533 - 538

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Citation Number: 5

Abstract

Abstract Sodium borohydride reduction of 5, 8-dimethyl-3, 4-dihydronaphthalen-1-(2H)-one (4) yielded 5, 8-dimethyl-1, 2, 3, 4-tetrahydro-1-naphthol (5). The tetralol 5 on Vilsmeier- Haack reaction with N, N-dimethylacetamide yielded 1-(5, 8-dimethyl-3, 4-dihydro-2- naphthyl) ethan-1-one (7) which on hydrogenation over Pd/C afforded 1-(5, 8-dimethyl-1, 2, 3, 4-tetrahydro-2-naphthyl) ethan-1-one (8). The tetralol 5 on Vilsmeier-Haack formylation ...