Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors

…, SW Yu, BH Cho, JD Park, JH Park, HS Lee…

Index: Choi, Seung-Su; Ji, Ae-Ri; Yu, Seung-Woo; Cho, Bong-Hwan; Park, Jung Dae; Park, Jun Hyoung; Lee, Hyun Soo; Ryu, Seong Eon; Kim, Dong Han; Kang, Jae-Hoon; Lee, Seung-Taek Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 6 p. 2032 - 2038

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Abstract

Matrix metalloproteinases (MMPs), a family of zinc-containing endopeptidases, participate in many normal processes such as embryonic development and wound repair, and in many pathological situations such as cancer, atherosclerosis, and arthritis. Peptidomimetic MMP inhibitors were designed and synthesized with N-formylhydroxylamine (retrohydroxamate) as a zinc-binding group and various side chains on the α, P1', and P2'positions. Using in ...

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