Amination of Aryl Iodides Using a Fluorous??Tagged Ammonia Equivalent

…, G Smith, M Begtrup, JL Kristensen

Index: Nielsen, Simon Dalsgaard; Smith, Garrick; Begtrup, Mikael; Kristensen, Jesper L. European Journal of Organic Chemistry, 2010 , # 19 p. 3704 - 3710

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Citation Number: 10

Abstract

Abstract A fluorous-tagged ammonia equivalent for the Cu-catalyzed amination of aryl iodides is described in which N-Boc-protected anilines are produced in high overall yield and purity. All purification steps are performed using Fluorous Solid-Phase Extraction (F- SPE) greatly simplifying and speeding up the isolation of the desired products.