21-[18F] fluoro-16. alpha.-ethyl-19-norprogesterone. Synthesis and target tissue selective uptake of a progestin receptor-based radiotracer for positron emission …

MG Pomper, JA Katzenellenbogen…

Index: Pomper; Katzenellenbogen; Welch; Brodack; Mathias Journal of medicinal chemistry, 1988 , vol. 31, # 7 p. 1360 - 1363

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Citation Number: 56

Abstract

We have synthesized 21-[18F] flu~ ro-16a-ethyl-19-n~ rpr~ gesterone (FENP), a high affinity ligand for the progesterone receptor, labeled with the positron-emitting radionuclide fluorine- 18 (tllz= 110 min). The synthesis proceeds in two steps from 21-hydroxy-16a-ethyl-19- norprogesterone and involves [lsF] fluoride ion displacement of the 21- trifluoromethanesulfonate (21-triflate). This material is purified by HPLC and is obtained in ...