(2-Chloroethyl) nitrosourea congeners of amino acid amides

…, T Kato, H Takino, T Hisamatsu

Index: Suami; Kato; Takino; Hisamatsu Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 829 - 832

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Citation Number: 46

Abstract

a The product was extracted with ethvl acekate from the nitrosation solution, which had been neutralized with a NaHCO, solution. Yield from L-prolinamide. 4-aminobutyramide (3)(see Table I). Method B: Carbamoylation of an amino acid amide with 2-chloroethyl isocyanate, followed by conventional nitrosation with sodium nitrite in 99% formic acid, gives the other 11 congeners (see Tables I1 and 111). In the latter method, there are two positions to be ...