2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide

Modify Date: 2024-01-19 09:51:58

2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide Structure
2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide structure
Common Name 2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide
CAS Number 65267-04-1 Molecular Weight 208.60300
Density 1.58g/cm3 Boiling Point N/A
Molecular Formula C5H9ClN4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name 2-[[2-chloroethyl(nitroso)carbamoyl]amino]acetamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.58g/cm3
Molecular Formula C5H9ClN4O3
Molecular Weight 208.60300
Exact Mass 208.03600
PSA 104.86000
LogP 0.49470
Index of Refraction 1.597

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS4552830
CHEMICAL NAME :
Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-3-nitroso-
CAS REGISTRY NUMBER :
65267-04-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C5-H9-Cl-N4-O3
MOLECULAR WEIGHT :
208.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21230 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22400 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982

 Synthetic Route

~40%

2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide Structure

2-[(2-chloroeth...

CAS#:65267-04-1

Literature: Eisenbrand; Gerhard Patent: US4150146 A1, 1979 ;

~73%

2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide Structure

2-[(2-chloroeth...

CAS#:65267-04-1

Literature: Suami; Kato; Takino; Hisamatsu Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 829 - 832

~51%

2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide Structure

2-[(2-chloroeth...

CAS#:65267-04-1

Literature: Sosnovsky; Gnewuch Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 7 p. 989 - 998

 Synonyms

1-(Carbamoylmethyl)-3-(2-chloroethyl)-3-nitrosourea
Urea,1-(carbamoylmethyl)-3-(2-chloroethyl)-3-nitroso
N-<N'-(2-chloroethyl)-N'-nitrosocarbamoyl>glycinamide
2-(3-(2-chloroethyl))-3-nitrosoureido acetamide
n2-[(2-chloroethyl)(nitroso)carbamoyl]glycinamide