Synthesis of Benzothiazoles through Copper??Catalyzed One??Pot Three??Component Reactions with Use of Sodium Hydrosulfide as a Sulfur Surrogate

…, Y Heo, MR Kumar, Y Kim, KH Song…

Index: Park, Namjin; Heo, Yumi; Kumar, Manian Rajesh; Kim, Yong; Song, Kwang Ho; Lee, Sunwoo European Journal of Organic Chemistry, 2012 , # 10 p. 1984 - 1993

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Citation Number: 12

Abstract

Abstract Copper-catalyzed one-pot three-component reactions of 2-iodoanilines, aldehydes, and NaSH· n H 2 O afford benzothiazoles in good yields. When CuCl was employed as a catalyst in the absence of a ligand, a variety of aromatic aldehydes and substituted 2- iodoanilines reacted with NaSH· n H 2 O to produce the corresponding 2-arylbenzothiazoles in 70–98% yields. The copper catalyst plays a key role in C–S bond formation between ...