Rearrangement of N-(alkylamino) azoles in acid media: a new entry to C-amino-N-substituted azoles

…, M Espada, C Avendano, RM Claramunt…

Index: Salazar, Loreto; Espada, Modesta; Avendano, Carmen; Claramunt, Rosa Maria; Sanz, Dionisia; Elguero, Jose Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1563 - 1567

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Citation Number: 14

Abstract

Conclusions A delicate balance of factors is necessary to observe the rearrangement of N- aminoazoles into &amino derivatives. These conditions are (i) the absence of substituents at position 3 of pyrazoles and indazoles,(ii) the absence of other nitrogen atoms in the ring,(iii) that alkyl groups yield cleaner results than aralkyl groups, since for the latter a mixture of rearrangement and transalkylation reactions