Synthesis

Further metalations and functionalizations of chloro-, bromo-and iodo (trifluoromethyl) pyridines

…, M Marull, F Mongin, D Espinosa, M Schlosser

Index: Cottet, Fabrice; Marull, Marc; Mongin, Florence; Espinosa, David; Schlosser, Manfred Synthesis, 2004 , # 10 p. 1619 - 1624

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Citation Number: 14

Abstract

Abstract In accordance with the concept of regioexhaustive functionalization, both 3-chloro-2- (trifluoromethyl) pyridine and 2-bromo-6-(trifluoromethyl) pyridine were converted each time into the three possible carboxylic acids (1, 4 and 5 and 6, 9 and 12, respectively). 2-Bromo-4- (trifluoromethyl) pyridine, 2-bromo-5-(trifluoromethyl) pyridine, 2-iodo-4-(trifluoromethyl) pyridine and 4-iodo-2-(trifluoromethyl) pyridine were selectively deprotonated and ...