Syntheses of dual??radioisotope??labeled CP??I, a GABAA receptor partial agonist

Y Zhang, L Greenfield, Y Hong

Index: Zhang, Yinsheng; Greenfield, Laura; Hong, Yang Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 8 p. 411 - 417

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Abstract

Abstract CP-I is a potent subtype-selective GABA A receptor partial agonist. Owing to its significant metabolic cleavage at C 8 observed in preliminary biotransformation studies with non-radiolabeled CP-I, the syntheses of CP-I labeled at the right or left hand side with 14 C or labeled with 3H at the right hand side were required. The two compounds labeled with 14 C at the left or right hand side were synthesized in 2 and 5 radio-synthetic steps using [14 ...