Synthesis and In??vitro Evaluation of Platelet Aggregation Inhibitory Activity of Paeonol and its Analogues

…, UM Thatte, NN Rege, SA Dahanukar

Index: Akamanchi; Padmawar; Thatte; Rege; Dahanukar Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 5 p. 323 - 329

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Citation Number: 5

Abstract

The compounds with the greatest anti-platelet potential among the series tested were 1-(2,5-dihydroxyphenyl )ethanone (65-36% inhibition at 300 μM against 5 μM ADP), paeonol (36.31%), 1-(2-hydroxy- 5-methoxyphenyl)ethanone (24.47%), 1-(2-hydroxy-5-nitro-phenyl) ethanone (30.40%) and 1-(5-chloro-2-hydroxy-4-methylphenyl)ethanone (24.43%). ... Copyright © 1999-2015 John Wiley & Sons, Inc. All Rights Reserved.