2,5-Dihydroxyacetophenone

Modify Date: 2025-08-27 13:27:53

2,5-Dihydroxyacetophenone structure	Common Name	2,5-Dihydroxyacetophenone
	CAS Number	490-78-8	Molecular Weight	152.147
	Density	1.3±0.1 g/cm3	Boiling Point	329.2±27.0 °C at 760 mmHg
	Molecular Formula	C₈H₈O₃	Melting Point	204-206 °C(lit.)
	MSDS	Chinese USA	Flash Point	167.1±20.2 °C

Use of 2,5-Dihydroxyacetophenone

2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways[1].

Name	2',5'-Dihydroxyacetophenone
Synonym	More Synonyms

Description	2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK1 ERK2 NF-κB
In Vitro	2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells[1].
References	[1]. Han Y, et al. 2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatoryresponses in lipopolysaccharide-stimulated RAW264.7 macrophages. J Med Food. 2012 Jun;15(6):505-10.

Density	1.3±0.1 g/cm3
Boiling Point	329.2±27.0 °C at 760 mmHg
Melting Point	204-206 °C(lit.)
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	167.1±20.2 °C
Exact Mass	152.047348
PSA	57.53000
LogP	1.59
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.595
Water Solubility	insoluble

2,5-Dihydroxyacetophenone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM7700000

CHEMICAL NAME :: Acetophenone, 2',5'-dihydroxy-

CAS REGISTRY NUMBER :: 490-78-8

BEILSTEIN REFERENCE NO. :: 0637903

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QR CQ BV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,140,1953

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AM7700000
HS Code	29145000

Precursor 10
CAS#:1205-91-0 p-Diacetoxybenzene CAS#:1201-38-3 1-(2,5-Dimethox... CAS#:64-19-7 acetic acid CAS#:123-31-9 Hydroquinone
CAS#:127-17-3 Pyruvic acid CAS#:106-51-4 1,4-Benzoquinone CAS#:3233-32-7 4-Acetoxyphenol CAS#:874-23-7 2-Acetylcyclohe...
CAS#:75-36-5 Acetyl chloride CAS#:1125-55-9 2-Acetyl-1,4-be...
DownStream 9
CAS#:113495-13-9 phenyl-bis[3-(6... CAS#:4250-77-5 6-hydroxyflavanone CAS#:132361-70-7 3-benzylidene-2... CAS#:533-73-3 1,2,4-Trihydrox...
CAS#:39679-60-2 Nitrogenistein CAS#:140660-42-0 1-(2,5-dihydrox... CAS#:42059-79-0 3-Formyl-6-meth... CAS#:204703-66-2 3-(4-chlorophen...
CAS#:19312-13-1 1-(2,5-dihydrox...

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2,5-Dihydroxyacetophenone: a matrix for highly sensitive matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of proteins using manual and automated preparation techniques Wenzel, Thomas; Sparbier, Katrin; Mieruch, Thorsten; Kostrzewa, Markus

Rapid Commun. Mass Spectrom. 20 , 785-789, (2005)

Ethanone, 1- (2,5-dihydroxyphenyl)-

2,5-Dihydroxyphenyl methyl ketone,2-Acetyl-1,4-dihydroxybenzene,2-Acetylhydroquinone

2’,5’-Dihydroxyacetophenone

1-(2,5-Dihydroxyphenyl)ethanone

2',5'-Dihydroxyacetophenone

2',5'-Dihydroxy acetophenone

Quinacetophenone

EINECS 207-716-4

2-Acetylhydroquinone

2‘,5‘-Dihydroxyacetophenone

Ethanone, 1-(2,5-dihydroxyphenyl)-

MFCD00002343

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2,5-Dihydroxyacetophenone
Price: Check
Purity: 99.0%
Delivery: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2,5-Dihydroxyacetophenone
Price: ￥538.0/100g ￥198.0/25g
Purity: 98.0%
Delivery: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2',5'-Dihydroxyacetophenone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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2,5-Dihydroxyacetophenone

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