Tetrahedron

Microwave-assisted expeditious synthesis of 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2-ones

B Yang, L Shi, JJ Wu, X Fang, X Yang, F Wu

Index: Yang, Bo; Shi, Luyan; Wu, Jingjing; Fang, Xiang; Yang, Xueyan; Wu, Fanhong Tetrahedron, 2013 , vol. 69, # 15 p. 3331 - 3337

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Citation Number: 5

Abstract

An efficient and convenient protocol for synthesis of 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2- ones is described. The reaction of allyl (aryl/alkyl) carbamates with fluoroalkyl iodide initiated by sodium dithionite in aqueous acetonitrile resulted in adducts that undergoes a cyclization assisted by microwave irradiation to form 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2- ones with high yields. It was also found that the products can be more efficiently formed ...