Mercaptoacyl aminoacid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives

…, EM Smith, TL Nechuta, AA Bronnenkant…

Index: Neustadt; Smith; Nechuta; Bronnenkant; Haslanger; Watkins; Foster; Sybertz Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2461 - 2476

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Citation Number: 14

Abstract

The atrial natriuretic factors (ANF) are peptide hormones first isolated from cardiac atrial tissue. l Related peptidic hormones, brain natriuretic peptide2 and~ rodilatin,~ have been identified. Many pharmacological actions have been demonstrated for ANF, most prominently vasorelaxant and natriuretic a~ tivities.~ The half-life of these peptides in circulation is quite with proteolytic cleavage occurring in several positions, 6 but ...