Organic letters

One-Pot Synthesis of 4-Substituted 3-Amino-2-cyanothiophenes Involving O-Ethyl Thioformate

H Zhang, MS Bednarz, NK Lim, G Hernandez…

Index: Wu-Yun Ren; Rao; Klein Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1757 - 1763

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Citation Number: 5

Abstract

An efficient one-pot synthesis of 4-substituted 3-amino-2-cyanothiophenes is described. Treatment of 2-alkyl or aryl substituted acetonitrile sequentially with 2.1 equiv of LDA, 1.1 equiv of O-ethyl thioformate, and 1.2 equiv of 2-chloroacetonitrile afforded the thiophenes in