Synthesis of highly enantioenriched 3, 4-dihydroquinolin-2-ones by 6-exo-trig radical cyclizations of axially chiral α-halo-ortho-alkenyl anilides

DB Guthrie, SJ Geib, DP Curran

Index: McAllister, Laura A.; Turner, Kristy L.; Brand, Stephen; Stefaniak, Mark; Procter, David J. Journal of Organic Chemistry, 2006 , vol. 71, # 17 p. 6497 - 6507

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Citation Number: 21

Abstract

... Journal of the ... J. Am. ... Procter and co-workers have developed a general approach to racemic dihydroquinolin-2-ones by using intramolecular conjugation addition of α-arene sulfonyl anilides.(13) For example, base-promoted cyclization of 8 followed by reductive desulfonylation ...