Acetazolamide-based fungal chitinase inhibitors

AW Schüttelkopf, L Gros, DE Blair, JA Frearson…

Index: Schuettelkopf, Alexander W.; Gros, Ludovic; Blair, David E.; Frearson, Julie A.; Van Aalten, Daan M.F.; Gilbert, Ian H. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 23 p. 8334 - 8340

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Citation Number: 23

Abstract

Chitin is an essential structural component of the fungal cell wall. Chitinases are thought to be important for fungal cell wall remodelling, and inhibition of these enzymes has been proposed as a potential strategy for development of novel anti-fungals. The fungal pathogen Aspergillus fumigatus possesses two distinct multi-gene chitinase families. Here we explore acetazolamide as a chemical scaffold for the inhibition of an A. fumigatus 'plant-type' ...