The Journal of organic chemistry

Decarboxylative Trichloromethylation of Aromatic Aldehydes and Its Applications in Continuous Flow

AB Jensen, AT Lindhardt

Index: Jensen, Andreas B.; Lindhardt, Anders T. Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1174 - 1183

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Citation Number: 8

Abstract

Two new protocols for the efficient synthesis of 2, 2, 2-trichloromethylcarbinols, starting from aromatic aldehydes, have been developed. A combination of sodium trichloroacetate in the presence of malonic acid proved efficient for the transformation of electron deficient aldehydes using DMSO as solvent. Electron-rich aldehydes did, however, not require the addition of malonic acid, affording the desired 2, 2, 2-trichloromethylcarbinols without a ...