Organic & biomolecular chemistry

Copper (ii)-catalyzed C–O coupling of aryl bromides with aliphatic diols: synthesis of ethers, phenols, and benzo-fused cyclic ethers

Y Liu, SK Park, Y Xiao, J Chae

Index: Liu, Yajun; Park, Se Kyung; Xiao, Yan; Chae, Junghyun Organic and Biomolecular Chemistry, 2014 , vol. 12, # 26 p. 4747 - 4753

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Citation Number: 12

Abstract

A highly efficient copper-catalyzed C–O cross-coupling reaction between aryl bromides and aliphatic diols has been developed employing a cheaper, more efficient, and easily removable copper (II) catalyst. A broad range of aryl bromides were coupled with aliphatic diols of different lengths using 5 mol% CuCl2 and 3 equivalents of K2CO3 in the absence of any other ligands or solvents to afford the corresponding hydroxyalkyl aryl ethers in good ...